منابع مشابه
The gastric precancerous cascade.
Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first "complete" and then ...
متن کاملNoncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends on infection by Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV), host genetic factors, and environmental factors. The heterogeneity of the disease has begun to ...
متن کاملGastric Intestinal Metaplasia: An Intermediate Precancerous Lesion in the Cascade of Gastric Carcinogenesis.
Gastric intestinal metaplasia, an intermediate lesion in the development of intestinal-type gastric cancer, is observed in the milieu of long standing non-atrophic gastritis and atrophic gastritis. Most patients with intestinal metaplasia remain asymptomatic unless cobalamin deficiency occurs secondary to loss of glands (that produce intrinsic factor and acid). Genetic events that predispose to...
متن کاملExpression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions
The histone γH2AX is a marker of activated DNA damage that is overexpressed in various cancers and corresponding precursor lesions, indicating that γH2AX is a component in oncogenic transformation. The present study aimed to determine whether the immunohistochemical expression of γH2AX is involved in the progression between superficial gastritis (n=20), atrophic gastritis (n=24) and gastric car...
متن کاملEndoscopic diagnosis of early gastric cancer and precancerous lesion
BACKGROUND Gastric carcinoma is one of the most common malignant tumors and is the second commonest reason of cancer deaths worldwide. It is very important to detect gastric cancer at the early stage or the precancerous lesion in stomach in order to improve the prognosis of gastric cancer. However, it is still a clinical challenge because of the lack of any tell-tale gross endoscopic signs. The...
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ژورنال
عنوان ژورنال: Journal of Digestive Diseases
سال: 2011
ISSN: 1751-2972
DOI: 10.1111/j.1751-2980.2011.00550.x